Agonist API GW501516 white powder

Products Details

GW 501516 is an agonist of PPARδ with EC50 value of 1.1 nM. GW501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1. 1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and -γ. GW501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx)cells. GW501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner. GW501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.Email : whatsapp: +8619832408762 wickr: fairyqf Skype:+8619832408762

Common name


English name


CAS number


molecular weight



1.4±0.1 g/cm3

boiling point

584.5±60.0 °C at 760 mmHg

molecular formula


melting point




flash point

307.3±32.9 °C

Contact us

Please feel free to give your inquiry in the form below We will reply you in 24 hours